Nana Ama Konadu Yiadom III was born in 1927 to the 13th Asantehemaa, Nana Afia Kobi Serwaa Ampem II (1977-2016), and Opanin Kofi Foffie, also known as Koofie or Keewuo of Besease near Atimatim, a suburb of Kumasi.
He was a carpenter by profession.
Nana Ama Konadu Yiadom III, the 14th Queen Mother of Asante, was the firstborn of Asantehemaa Nana Afia Kobi's five children, the youngest of whom is Asantehene, .
In her teens, traditional puberty rites were performed for her to usher her into womanhood.
