The incident, which took place on Dzanie Ashie Street, involved a high-speed collision between a Jaguar and an Acura, both of which burst into flames upon impact.
Preliminary reports from the police identify the driver of the Jaguar as 16-year-old Erald Amoako, son of the renowned Ghanaian pastor, Salifu Amoako.
According to witnesses and CCTV footage, the teenager was allegedly speeding recklessly moments before crashing into the Acura.
The two girls in the Acura, believed to be aged 11 and 12, were trapped in the vehicle and burned beyond recognition.