The opening weekend of the 2025/26 Ghana Premier League is packed with drama, featuring tricky away fixtures for former champions.

Medeama SC hit the road to face Young Apostles, while FC Samartex travel to Vision FC to begin their title pursuit.

Premier League returnees Swedru All Blacks FC and Eleven Wonders FC will also start away from home, facing Nations FC and Basake Holy Stars, respectively.

Last season's runners-up Heart of Lions begin their campaign at home against Dreams FC, with another finely balanced clash set as Karela United host Aduana FC in Aiyinase.