West Ham midfielder Mohammed Kudus missed a last-gasp penalty as the Black Stars suffered a 2-1 defeat to Niger in their final 2025 Africa Cup of Nations (AFCON) qualifier at the Accra Sports Stadium.
The loss capped off a disastrous campaign for Ghana, who finished bottom of Group F without a single victory.
Ghana's struggles were evident throughout the qualifiers, managing only three goals in six matches.
Group F was topped by Angola and Kwesi Appiah's Sudan, both securing qualification for the AFCON in Morocco.