Ghana will be without Leicester City duo Jordan Ayew and Fatawu Issahaku, along with defenders Alidu Seidu and Gideon Mensah, for Monday's final AFCON 2025 qualifier against Niger.
The four players featured in Friday's 1-1 draw against Angola, which ended Ghana's hopes of qualifying for the tournament in Morocco next year.
Ayew, who scored a stunning free-kick, Issahaku, Mensah and Seidu have been ruled out due to injuries sustained during the Angola match, the Ghana FA confirmed.
Both Seidu and Mensah, who had passed late fitness tests to play on Friday, were sidelined after post-match medical assessments deemed them unfit.