Manchester United will visit Tottenham Hotspur in the Carabao Cup quarter-finals.Holders Liverpool will visit Premier League strugglers Southampton.Arsenal host Crystal Palace in a London derby, while Newcastle United are at home to Brentford.The quarter-final ties will take place in the week of 16 December.It is the first time in 14 years there have been no EFL clubs in the League Cup quarter-finals.Spurs beat Manchester City in the fourth round, while United - who beat Leicester 5-2 under interim boss Ruud van Nistelrooy - will hope to have Ruben Amorim in charge by then.EFL Cup quarter-finals:Tottenham v Manchester UnitedArsenal v Crystal PalaceNewcastle v BrentfordSouthampton v Liverpool