Young Apostles host Hearts of Oak for their first-ever top-flight encounter at the Wenchi Sports Stadium.
The game promises to be an intriguing clash, as a win for either side will lift them from the bottom half of the table.
Both teams are on the same run of form, with one win, two losses, and two draws in their first five league games.
The home side will be looking to win back-to-back home games for the first time in their debut season as they face one of the worst away sides.