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Asante Kotoko are in dire need of a win in this game to secure a place in the quarter-finals of the competition. Zesco United will also be playing for pride as they have no chance of qualifying out of the group.
The first leg between this two sides ended 2-1 in favor of Asante Kotoko on match day two at the Baba Yara Sports Stadium.
Asante Kotoko last trip to Zambia ended in a defeat as they lost 3-1 to Nkana FC on match day four.
CK Akonnor has handed debut start to Ivorian Dang Zabo Teguy to replace suspended Sogne Yacouba.
The former Manzini FC player has been handed the opportunity to play his first match for the club since signing in January.
Akonnor has also replaced Habib Mohammed with Martin Antwi who started in the 1-1 draw with Al Hilal last week at home.
Below is the starting line up of both teams
Asante Kotoko Starting XI:
Felix Annan- Amos Frimpong, Daniel Darkwah, Emmanuel Agyemang-Badu, Wahab Adams- Habib Mohammed, Umar Bashir, Kwame Bonsu-Emmanuel Gyamfi, Abdul Fatawu Safiu, Dang Zabo Teguy.